NEUTROPHIL MIGRATION IS INFLUENCED BY SUBSTRATE STIFFNESS
نویسندگان
چکیده
منابع مشابه
Neutrophil morphology and migration are affected by substrate elasticity.
To reach sites of inflammation, neutrophils execute a series of adhesion and migration events that include transmigration through the vascular endothelium and chemotaxis through the vicinal extracellular matrix until contact is made with the point of injury or infection. These in vivo microenvironments differ in their mechanical properties. Using polyacrylamide gels of physiologically relevant ...
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Circulating barrier disruptive agonists bind specific cell membrane receptors and trigger signal transduction pathways leading to the activation of cell contractility and endothelial cell (EC) permeability. Although all cells in tissues including vascular EC are surrounded by compliant extracellular matrix, the impact of matrix stiffness on agonist-induced signaling, cytoskeletal remodeling and...
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Gulley et all have recently reported increased neutrophil myeloperoxidase (MPO) activity in 10 anemic patients demonstrated by the Technicon H* l instrument (Technicon Instruments Corp, Tarrytown, NY). Dash et ai2 have commented on this report for not considering the balance of smokers to nonsmokers. We would like to comment further on this report. It has been shown by us that the neutrophil MP...
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A vast amount of work has been dedicated to the effects of shear flow and cytokines on leukocyte transmigration. However, no studies have explored the effects of substrate stiffness on transmigration. Here, we investigated important aspects of endothelial cell contraction-mediated neutrophil transmigration using an in vitro model of the vascular endothelium. We modeled blood vessels of varying ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.929.6